![[NUVISAN Talk] Targeting RAS via SOS1 from tsa sales locations Video Screenshot Preview](https://cdn9.hifimov.co/picture/original/nUE0pUZ6Yl9cYaMcoJIiL_EhYzAioF9_nJEyol8kAGZjBQD5BGN3YGOwMJSwAzL-ZwIvBQH1MwplMJL-ZzWwAGxmBQR3LmywMGL5AQt_ZGxlAwSxAmuxLwN3MQx3MzLmMJVlBTLjMGtgMS8lZQO-ZGHjXFfbXRucEzyAo3LhL_8cKmR1ZmN-AQx5ZQpgZTAyLJZ_MwtlAJV-AGIzAmWyMwtlLzZ1BGZ-ZGqwBJAyAwx0BQLkBGV_ZJD3BTEvZQqxBGqzMwAyLwV-MwOyBP1xYGVjZUtkAGN5v7P/(HiFiMov.co)_nuvisan-talk-targeting-ras-via-sos1.jpg "[NUVISAN Talk] Targeting RAS via SOS1 from tsa sales locations Video Screenshot Preview")
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⏲ Duration: 31 min 27 sec
✓ Published: 20-Oct-2022
✓ Published: 20-Oct-2022
Description:
The application of multiple biophysical techniques to validate initial HTS hits has become an important part of lead discovery. To decipher the mode of action of a new SOS1 inhibitor class, biophysics coupled with the intensive use of structural biology was instrumental.nnIn this case study, we targeted RAS via SOS1, its guanine nucleotide exchange factor. A combination of HTS and fragment screening resulted in the discovery of the first nanomolar SOS1 inhibitors which disrupt the interaction be
The application of multiple biophysical techniques to validate initial HTS hits has become an important part of lead discovery. To decipher the mode of action of a new SOS1 inhibitor class, biophysics coupled with the intensive use of structural biology was instrumental.nnIn this case study, we targeted RAS via SOS1, its guanine nucleotide exchange factor. A combination of HTS and fragment screening resulted in the discovery of the first nanomolar SOS1 inhibitors which disrupt the interaction be
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